As with most games with in app purchases, the question is have they designed the game around them, making them necessary to progress and enjoyment, or is the game playable without?
Ive played through the first forty levels or so, and the game is actually quite enjoyable. The puzzles and mechanics work, and you should enjoy the game if you enjoy such puzzles. The in app purchases are time based: you only have so many tickets that allow you to play at any one time, and these tickets are reduced each time you play a level. When you run out of tickets, you can either wait a few minutes and the game will give you one, or you can spend real money to buy more and play immediately.
Overall I find that the IAPs have no impact of the puzzles themselves, only on how many of them you can do at one time. The game part isnt based around squeezing you dry, in other words.
Its a fun game, and if youre patient enough to wait for tickets, one which it seems you can enjoy without spending any money at all, with only seeing brief ads. I say try it for yourself, as I did have fun with it.
Effective Against Plaque about Rail Maze 2: Train puzzle game, v1.1.4